RAEng / Leverhulme Trust Research Fellowships 2023
Hemarthrosis, or articular bleeding due to trauma or diseases such as haemophilia, lead to highly degenerated joints, in a systemic disease resembling osteoarthritis. There is no targeted treatment due in part to the lack of mechanistic understanding of the disease. There is therefore a critical need to develop fundamental models of the disease which can enable development and evaluation of new treatments.
The project will develop mathematical models of how bone remodelling is affected by articular bleeds, providing an understanding on how biochemical changes in the bone environment change both the bone properties and its function or morphology. COMP-HA proposes to use two approaches of computer modelling, based on recent advances in both computational biology and image-based computational biomechanics, integrating the multiscale features of the disease.
LinkedIn: https://uk.linkedin.com/in/marlenemengoni
Twitter: @mengomarlene
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